20xx年全国高考模拟参考部分
报告简介：
Title: Computationally reconstructing the evolutionary history of mammalian genomes
Abstract:
Data generated from numerous mammalian genome sequencing projects have provided an unprecedented opportunity to use comparative genomics to computationally reconstruct the trajectory of all the genetic changes leading to modern placental mammals since their common ancestor living approximately 100 million years ago. However, this task is algorithmically extremely challenging. On a small scale, genomes have undergone point mutations, small insertions and deletions. More dramatically, at a larger scale,
rearrangements, duplications, large insertions and deletions have led to varied karyotypes. In this talk, I will introduce several computational methods we developed, including an algorithm that predicts the ancestral karyotype based on modern species and a model that enables us to reconstruct evolutionary histories involving complex genomic operations. Finally, I will discuss a number of ongoing projects and future plans in order to more efficiently and more accurately document the detailed changes in genome evolution, and to discover how evolution has shaped us at the molecular level.
报告人简介：
Jian Ma will be joining the Department of Bioengineering at the University of Illinois at Urbana-Champaign as an Assistant Professor in August 2009. He has been a postdoc with David Haussler in the Center for Biomolecular Science and Engineering at the University of California, Santa Cruz, since January 2007. His research interests lie at the intersection of computer science, genomics, and evolutionary biology. He develops computational methods to explore the human genome, integrating cross-species comparative genomics data to understand mammalian evolution and human genetics. He received his Ph.D. under the
supervision of Webb Miller in December 2006 from The Pennsylvania State University. He also received his BS and MS degrees, in 2000 and 2003 respectively, from Fudan University, Shanghai, China.